Stasis Thrombi Induced by Bacterial Endotoxin.

• Previous studies in this laboratory have indicated that a combination of systemic hypercoagulability and retarded blood flow is capable of producing a red thrombus in the veins of animals. The hypothesis has been proposed that activation of the procoagulants involved in the formation of intrinsic thromboplastin produces massive thrombosis in large vessels in areas of markedly reduced blood flow. The purpose of this report is to provide evidence that single infusions of bacterial endotoxin are capable of inducing stasis thrombi in rabbits. Furthermore, data will be presented suggesting that this thrombogenic effect of endotoxin may be mediated in part through its action on a blood coagulation factor, plasma thromboplastin antecedent (Factor XI).